The Chemical Biology Consortium (CBC) is the discovery engine of the NExT Program. Established in 2009, NCI's CBC was designed to be a flexible network of scientists working to increase the flow of early-stage cancer drug candidates into the NExT development pipeline. In April 2016, the CBC network was expanded from 12 to 22 centers, including 7 dedicated centers and 15 specialized centers, with the resources to advance early stage drug discovery projects through to the clinical candidate stage.
Additionally, the highly successful Developmental Therapeutics Program (DTP) provides the resources needed to facilitate the preclinical development to first-in-human studies. The program is also complemented by the Center for Cancer Research's (CCR) dynamic in-house research.