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NIH - National Institutes of Health National Cancer Institute Division of Cancer Treatment and Diagnosis Center for Cancer Research
NCI Experimental Therapeutics Program (NExT)
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Last Updated: 06/03/19

Screening/Hit-to-Lead Stage NExT Projects

Applicant Institute Project
Fesik, Stephen Vanderbilt University Discovery of small molecule, direct inhibitors of oncogenic Wnt signaling
Hsieh, James Memorial Sloan Kettering Cancer Center Optimization of Lead Small Molecule Inhibitors of Taspase 1 for Cancer Therapeutics
Lengyel, Ernst The University of Chicago Targeting the stromal epigenome with small molecule inhibitors of NNMT
Lieber, Michael University of Southern California Inhibitors of the Artemis Endonuclease for Cancer Chemotherapy
Moscat, Jorge Sanford Burnham Prebys Medical Discovery Institute Inhibitors of Phosphoglycerate Dehydrogenase: A Cancer Metabolism Target
Tautz, Lutz Sanford Burnham Prebys Medical Discovery Institute Novel Screen for Allosteric SHP2 Inhibitors